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Human Mucin-1/MUC-1 Isoform Y Protein, Ultra Low Endotoxin (MUC-HM2Y1-UL) Summary
Product Description |
Recombinant Human Mucin-1/MUC-1 Isoform Y Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Ser24-Gly158. |
Product Background |
MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human Mucin-1/MUC-1 Isoform Y Protein, Ultra Low Endotoxin (MUC-HM2Y1-UL) Specifications/Details
Protein |
Mucin-1/MUC-1 |
Synonyms |
MUC1/Y; MUC1; MUC-1; Mucin-1; Mucin1; CA 15-3; Episialin; H23AG; KL-6; PEMT; PUM; PEM; EMA; CD227; |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ser24-Gly158 |
Molecular Weight |
The protein has a predicted MW of 41.38 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc (IgG1) |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human Mucin-1 Isoform Y on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human Mucin-1 Isoform Y is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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