Human MUC18/CD146 Protein (MUC-HM118)
Human MUC18/CD146 Protein (MUC-HM118)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human MUC18, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MUC18, hFc Tag with the EC50 of 5.9ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Val24-Gly559
Catalog #MUC-HM118
Regular price $300.00
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Product Description

Recombinant Human MUC18/CD146 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val24-Gly559.

Product Background

METCAM/MUC18 is an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family. It can carry out common functions of CAMs which is to perform intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, to interact with various signaling pathways and to regulate general behaviors of cells.The above positive correlation is fortuitous; actually METCAM/MUC18 acts as a tumor and metastasis suppressor for the ovarian carcinoma cells.

Product Category

Recombinant Protein / Antibody discovery

Protein

MUC18/CD146

Synonyms

Gicerin; CD146; MCAM; MUC18

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Val24-Gly559

Molecular Weight

The protein has a predicted MW of 60.8 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.

Activity

Immobilized Human MUC18, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MUC18, hFc Tag with the EC50 of 5.9ng/ml determined by ELISA (QC Test). See testing image for detail.

Product Tag

C-His

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 24 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human MUC18, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MUC18, hFc Tag with the EC50 of 5.9ng/ml determined by ELISA (QC Test). Immobilized Human MUC18, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MUC18, hFc Tag with the EC50 of 5.9ng/ml determined by ELISA (QC Test).
Human MUC18 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human MUC18 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human MUC18 is greater than 95% as determined by SEC-HPLC. The purity of Human MUC18 is greater than 95% as determined by SEC-HPLC.

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