Human MUC18/CD146 Protein (MUC-HM118)
Human MUC18/CD146 Protein (MUC-HM118)
Human MUC18/CD146 Protein (MUC-HM118)
Human MUC18/CD146 Protein (MUC-HM118)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human MUC18, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MUC18, hFc Tag with the EC50 of 5.9ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Val24-Gly559
Catalog #MUC-HM118
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Product Description
 Recombinant Human MUC18/CD146 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val24-Gly559.
Product Background
 METCAM/MUC18 is an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family. It can carry out common functions of CAMs which is to perform intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, to interact with various signaling pathways and to regulate general behaviors of cells.The above positive correlation is fortuitous; actually METCAM/MUC18 acts as a tumor and metastasis suppressor for the ovarian carcinoma cells.
Product Category
 Recombinant Protein
Target
 MUC18/CD146
Synonyms
 Gicerin; CD146; MCAM; MUC18
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Val24-Gly559
Molecular Weight
 The protein has a predicted MW of 60.8 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human MUC18, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MUC18, hFc Tag with the EC50 of 5.9ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human MUC18, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MUC18, hFc Tag with the EC50 of 5.9ng/ml determined by ELISA (QC Test).
Human MUC18 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human MUC18 is greater than 95% as determined by SEC-HPLC.
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