Human Musk (muscle, skeletal receptor tyrosine-protein kinase) Protein (MUK-HM101)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
  • Amino Acid Range: Leu24-Thr495
Catalog #MUK-HM101
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Product Description
 Recombinant Human Musk (muscle, skeletal receptor tyrosine-protein kinase) Protein is expressed from HEK293 with His tag at the C-terminus.It contains Leu24-Thr495.
Product Background
 MuSK (muscle-specific kinase) is a receptor tyrosine kinase that plays a central signaling role in the formation of neuromuscular junctions (NMJs). MuSK is activated in a complex spatio-temporal manner to cluster acetylcholine receptors on the postsynaptic (muscle) side of the synapse and to induce differentiation of the nerve terminal on the presynaptic side.
Product Category
 Recombinant Protein
Target
 Musk (muscle, skeletal receptor tyrosine-protein kinase)
Synonyms
 EC:2.7.10.1; MuSK; Muscle-specific kinase receptor
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Leu24-Thr495
Molecular Weight
 The protein has a predicted MW of 53.46 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Bis-Tris PAGE result.
Product Tag
 C-His
Express System
 HEK293
Purity
 >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human Musk (muscle, skeletal receptor tyrosine-protein kinase) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human Musk (muscle, skeletal receptor tyrosine-protein kinase) is greater than 95% as determined by SEC-HPLC.

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