Product Description |
Recombinant Human Neuropilin-2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln23-Pro859. |
Product Background |
Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2). NRP2 is important for migration, antigen presentation, phagocytosis and cell-cell contact within the immune system. Additionally, posttranslational NRP2 modifications like polysialylation are crucial for the function of some immune cells. |
Product Category |
Recombinant Protein |
Target |
Neuropilin-2 |
Synonyms |
Neuropilin-2; NRP2; VEGF165R2; NP2; NPN2; PRO2714 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln23-Pro859 |
Molecular Weight |
The protein has a predicted MW of 95.4 kDa. Due to glycosylation, the protein migrates to 110-115 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human Neuropilin-2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human Neuropilin-2 is greater than 95% as determined by SEC-HPLC. |
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