Name: Human NKp30/NCR3/CD337 Protein (NKP-HM230)
Brand: KactusBio
SKU: NKP-HM230-100UG
Price: 240.0 USD
Availability: InStock

Human NKp30/NCR3/CD337 Protein (NKP-HM230)

Human NKp30, hFc Tag captured on CM5 Chip via Protein A can bind Human B7-H6, His Tag with an affinity constant of 48.67 nM as determined in SPR assay (Biacore T200).

Immobilized Human NKp30, hFc Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-NKp30 Antibody, hFc Tag with the EC50 of 2.5ng/ml determined by ELISA (QC Test).

Human NKp30 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human NKp30 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human NKp30, hFc Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-NKp30 Antibody, hFc Tag with the EC50 of 2.5ng/ml determined by ELISA (QC Test). The affinity constant of 48.67 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Leu19-Thr138

Catalog #NKP-HM230

Size

100UG

500UG

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Product Description	Recombinant Human NKp30/NCR3/CD337 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Leu19-Thr138.
Product Background	NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Product Category	Recombinant Protein / Antibody discovery

Protein	NKp30/NCR3/CD337
Synonyms	CD337; LY117; NCR3; NKp30; 1C7; MALS
Accession	AAH52582
Species	Human
Biotinylated	no
Amino Acid Range	Leu19-Thr138
Molecular Weight	The protein has a predicted MW of 39.8 kDa. Due to glycosylation, the protein migrates to 53-60 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human NKp30, hFc Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-NKp30 Antibody, hFc Tag with the EC50 of 2.5ng/ml determined by ELISA (QC Test). The affinity constant of 48.67 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human NKp30, hFc Tag captured on CM5 Chip via Protein A can bind Human B7-H6, His Tag with an affinity constant of 48.67 nM as determined in SPR assay (Biacore T200).
	Immobilized Human NKp30, hFc Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-NKp30 Antibody, hFc Tag with the EC50 of 2.5ng/ml determined by ELISA (QC Test).
	Human NKp30 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human NKp30 is greater than 95% as determined by SEC-HPLC.