Human NOGOR Protein (NOG-HM101) Summary
Product Description |
Recombinant Human NOGOR Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Cys27-Ser447. |
Product Background |
NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene.RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human NOGOR Protein (NOG-HM101) Specifications/Details
Protein |
NOGOR |
Synonyms |
Nogo receptor; RTN4R; NOGOR; NgR1; Nogo-66 receptor; NGR |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Cys27-Ser447 |
Molecular Weight |
The protein has a predicted MW of 46.4 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human NOGOR, His Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-NOGOR Antibody, hFc Tag with the EC50 of 5.6ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized Human NOGOR, His Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-NOGOR Antibody, hFc Tag with the EC50 of 5.6ng/ml determined by ELISA. |
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Human NOGOR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human NOGOR is greater than 95% as determined by SEC-HPLC. |
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