Human Notch 3 Protein (NOT-HM403)
Human Notch 3 Protein (NOT-HM403)
  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Ala40-Glu467
Catalog #NOT-HM403
Regular price $315.00
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Product Description
Recombinant Human Notch 3 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Ala40-Glu467.
Product Background
Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs
Product Category
Recombinant Protein
Target
Notch 3
Synonyms
CADASIL; Notch homolog 3; Notch-3; NOTCH3
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Ala40-Glu467
Molecular Weight
The protein has a predicted MW of 47.7 kDa. Due to glycosylation, the protein migrates to 53-60 kDa based on Bis-Tris PAGE result.
Product Tag
C-His-Avi
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human Notch 3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human Notch 3 is greater than 95% as determined by SEC-HPLC.

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