Human Notch 3 Protein (NOT-HM203)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Ala40-Glu467

Catalog: NOT-HM203

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Product Description Recombinant Human Notch 3 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ala40-Glu467.

Product Background

 Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs

Product Category

 Recombinant Protein

Target

 Notch 3
Synonyms CADASIL; CASILneurogenic locus notch homolog protein 3; Notch (Drosophila) homolog 3; notch 3Notch homolog 3 (Drosophila); Notch homolog 3; Notch3; Notch-3

Gene/Protein ID

 Q9UM47

Species

 Human

Exact Sequence

 Ala40-Glu467
Molecular Weight The protein has a predicted MW of 71.53 kDa. Due to glycosylation, the protein migrates to 75-83 kDa based on Tris-Bis PAGE result.

Product Tag

 C-hFc

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human Notch 3 is greater than 95% as determined by SEC-HPLC.
Human Notch 3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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