Name: Human NPC2 Protein (NPC-HM102)
Brand: KactusBio
SKU: NPC-HM102-100UG
Price: 223.3 USD
Availability: InStock

Catalog #NPC-HM102

Size

100UG

500UG

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Human NPC2 Protein (NPC-HM102) Summary

Product Description	Recombinant Human NPC2 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu20-Leu151.
Product Background	The Niemann Pick type C (NPC) proteins, NPC1 and NPC2, are involved in the lysosomal storage disease, NPC disease. The formation of a NPC1⁻NPC2 protein⁻protein complex is believed to be necessary for the transfer of cholesterol and lipids out of the late endosomal (LE)/lysosomal (Lys) compartments. Mutations in either NPC1 or NPC2 can lead to an accumulation of cholesterol and lipids in the LE/Lys, the primary phenotype of the NPC disease.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Human NPC2 Protein (NPC-HM102) Specifications/Details

Protein	NPC2
Synonyms	He1; EDDM1
Accession	P61916-1
Species	Human
Biotinylated	no
Amino Acid Range	Glu20-Leu151
Molecular Weight	The protein has a predicted MW of 15.67 kDa. Due to glycosylation, the protein migrates to 21-24 kDa and 27-35 kDa kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.