Human NPC2 Protein (NPC-HM102)
Catalog: NPC-HM102
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Product Description | Recombinant Human NPC2 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu20-Leu151. |
Product Background |
The Niemann Pick type C (NPC) proteins, NPC1 and NPC2, are involved in the lysosomal storage disease, NPC disease. The formation of a NPC1⁻NPC2 protein⁻protein complex is believed to be necessary for the transfer of cholesterol and lipids out of the late endosomal (LE)/lysosomal (Lys) compartments. Mutations in either NPC1 or NPC2 can lead to an accumulation of cholesterol and lipids in the LE/Lys, the primary phenotype of the NPC disease. |
Product Category |
Recombinant Protein |
Target |
NPC2 |
Gene/Protein ID |
P61916-1 |
Species |
Human |
Exact Sequence |
Glu20-Leu151 |
Molecular Weight | The protein has a predicted MW of 15.67 kDa. Due to glycosylation, the protein migrates to 21-24 kDa and 27-35 kDa kDa based on Tris-Bis PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Lyophilized |
Shipping | Shipped at ambient temperature. |
Formulation | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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