Human NPR1/NPRA Protein (NPR-HM301)

  • Express System: HEK293
  • Product Tag: C-mFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Gly33-Glu473

Catalog: NPR-HM301

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Product Description Recombinant Human NPR1/NPRA Protein is expressed from HEK293 with mFc (IgG1) tag at the C-terminus.It contains Gly33-Glu473.

Product Background

NPR1 (natriuretic peptide receptor 1), a receptor of ANP (atrial natriuretic peptide) whitch acting through NPR1, provokes hypotension. NPR1 was abundantly expressed in endothelial cells and smooth muscle cells of small arteries and arterioles. NPR1 plays a crucial role in ANP-mediated blood pressure regulation, presumably by a mechanism that is RGS2-dependent in the acute phase and RGS2-independent in the chronic phase.

Product Category

Recombinant Protein

Target

NPR1/NPRA

Gene/Protein ID

NP_000897.3

Species

Human

Exact Sequence

Gly33-Glu473
Molecular Weight The protein has a predicted MW of 74.56 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Tris-Bis PAGE result.

Product Tag

C-mFc

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Human NPR1 is greater than 95% as determined by SEC-HPLC.
Human NPR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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