Product Description |
Recombinant Human NRG1 Beta 1 Protein is expressed from HEK293 with His tag at the N-terminus.It contains Ser177-Glu241. |
Product Background |
Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor. |
Product Category |
Recombinant Protein |
Target |
NRG1 Beta 1 |
Synonyms |
Pro-NRG1; NRG1; GGF; HGL; HRGA; NDF; SMDF; Beta1; Beta1A |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ser177-Glu241 |
Molecular Weight |
The protein has a predicted MW of 8.57 kDa. Due to glycosylation, the protein migrates to 10-13 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human NRG1 Beta 1, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human Her3, hFc Tag with the EC50 of 35.8ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
N-His |
Express System |
HEK293 |
Purity |
>95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in 50mM NaAc, 150mM NaCl (pH 5.0). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Human NRG1 Beta 1, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human Her3, hFc Tag with the EC50 of 35.8ng/ml determined by ELISA (QC Test). |
|
|
Immobilized Human NRG1 Beta 1, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human Her4, hFc Tag with the EC50 of 33.4ng/ml determined by ELISA. |
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|
Human NRG1 Beta 1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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