Human NRG1 Beta 1 Protein (NRG-HM201)

Express System: HEK293
Product Tag: N-hFc
Purity: > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
Activity: Immobilized Human Her4, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Ser2-Lys246

Catalog: NRG-HM201

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Product Description	Recombinant Human NRG1 Beta 1 Protein is expressed from HEK293 with hFc tag at the N-terminus.It contains Ser2-Lys246.
Product Background	Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor.
Product Category	Recombinant Protein

Target	NRG1 Beta 1
Gene/Protein ID	Q02297-6
Species	Human
Exact Sequence	Ser2-Lys246
Molecular Weight	The protein has a predicted MW of 54.00 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human Her4, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA. See testing image for detail.
Product Tag	N-hFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human Her4, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA.
	The purity of Human NRG1 Beta 1 is greater than 90% as determined by SEC-HPLC.
	Human NRG1 Beta 1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.