Human NRG1 Beta 1 Protein (NRG-HM201)
  • Express System: HEK293
  • Product Tag: N-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human Her4, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Ser2-Lys246
Catalog #NRG-HM201
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Product Description
 Recombinant Human NRG1 Beta 1 Protein is expressed from HEK293 with hFc tag at the N-terminus.It contains Ser2-Lys246.
Product Background
 Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor.
Product Category
 Recombinant Protein
Target
 NRG1 Beta 1
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Ser2-Lys246
Molecular Weight
 The protein has a predicted MW of 54.00 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human Her4, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
 N-hFc
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human Her4, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA (QC Test).
Immobilized Human Her3, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 14.2ng/ml determined by ELISA.
Human NRG1 Beta 1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human NRG1 Beta 1 is greater than 95% as determined by SEC-HPLC.
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