Human NRG1 Beta 1 Protein (NRG-HM201)

  • Express System: HEK293
  • Product Tag: N-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human Her4, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Ser2-Lys246

Catalog: NRG-HM201

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Product Description Recombinant Human NRG1 Beta 1 Protein is expressed from HEK293 with hFc tag at the N-terminus.It contains Ser2-Lys246.

Product Background

Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor.

Product Category

Recombinant Protein

Target

NRG1 Beta 1
Accession

Species

Human

Amino Acid Range

Ser2-Lys246
Molecular Weight The protein has a predicted MW of 54.00 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human Her4, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA (QC Test). See testing image for detail.

Product Tag

N-hFc

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human Her4, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA (QC Test).
Immobilized Human Her3, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 43.8ng/ml determined by ELISA.
The purity of Human NRG1 Beta 1 is greater than 95% as determined by SEC-HPLC.
Human NRG1 Beta 1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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