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Human NY-ESO-1 TCR&CD3 Complex VLP (TCC-HM00V) Summary
Product Description |
Recombinant Human NY-ESO-1 TCR&CD3 Complex VLP is expressed from HEK293.It contains NY-ESO-1 specific TCR (1G4c113), CD3ε&CD3γ, CD3ε&CD3δ, and CD3ζ dimers. |
Product Background |
The 1G4c113 TCR is an engineered, affinity-matured variant of the 1G4 T-cell receptor that specifically recognizes the peptide fragment of NY-ESO-1 (SLLMWITQC) presented on the HLA-A*02:01. Cluster of Differentiation 3 (CD3) is a multimeric protein complex and T cell co-receptor that plays an essential role in adaptive immune responses. These CD3 dimers bind non-covalently to the TCR to form the TCR&CD3 complex on the cell surface. |
Product Category |
Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / VLP |
Human NY-ESO-1 TCR&CD3 Complex VLP (TCC-HM00V) Specifications/Details
Protein |
NY-ESO-1 TCR&CD3 |
Synonyms |
NY-ESO-1 TCR&CD3 |
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
NY-ESO-1 specific TCR (1G4c113), CD3ε&CD3γ, CD3ε&CD3δ, and CD3ζ dimers |
Activity |
Immobilized Human NY-ESO-1 TCR&CD3 Complex VLP at 5 ug/mL (100ul/well) on the plate. Dose response curve for OKT3, mFc Tag with the EC50 of 3.6ng/ml determined by ELISA. |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 300mM L-arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Human NY-ESO-1 TCR&CD3 Complex VLP at 5 ug/mL (100ul/well) on the plate. Dose response curve for OKT3, mFc Tag with the EC50 of 3.6ng/ml determined by ELISA. |
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Immobilized Human NY-ESO-1 TCR&CD3 Complex VLP at 5 ug/mL (100ul/well) on the plate. Dose response curve for Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer, His Tag (Cat. MHC-HM405) with the EC50 of 7.5ng/ml determined by ELISA. |
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The purity of Human NY-ESO-1 TCR&CD3 Complex VLP is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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