• Express System: HEK293
  • Purity: > 95% as determined by HPLC
  • Activity: Immobilized Human NY-ESO-1 TCR&CD3 Complex VLP at 5 ug/mL (100ul/well) on the plate. Dose response curve for OKT3, mFc Tag with the EC50 of 18.2ng/ml determined by ELISA.
  • Amino Acid Range: NY-ESO-1 specific TCR (1G4c113), CD3ε&CD3γ, CD3ε&CD3δ, and CD3ζ dimers
Catalog #TCC-HM00V
Price
Regular price $1,23500
Regular price Sale price $1,23500
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Size
Avantor VWR Fisher Scientific

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Human NY-ESO-1 TCR&CD3 Complex VLP (TCC-HM00V) Summary

Product Description

 Recombinant Human NY-ESO-1 TCR&CD3 Complex VLP is expressed from HEK293.It contains NY-ESO-1 specific TCR (1G4c113), CD3ε&CD3γ, CD3ε&CD3δ, and CD3ζ dimers.

Product Background

 The 1G4c113 TCR is an engineered, affinity-matured variant of the 1G4 T-cell receptor that specifically recognizes the peptide fragment of NY-ESO-1 (SLLMWITQC) presented on the HLA-A*02:01. Cluster of Differentiation 3 (CD3) is a multimeric protein complex and T cell co-receptor that plays an essential role in adaptive immune responses. These CD3 dimers bind non-covalently to the TCR to form the TCR&CD3 complex on the cell surface.

Human NY-ESO-1 TCR&CD3 Complex VLP (TCC-HM00V) Specifications/Details

Protein
 NY-ESO-1 TCR&CD3
Synonyms
 NY-ESO-1 TCR&CD3;NY-ESO1TCR&CD3
Species
 Human
Biotinylated
 no
Amino Acid Range
 NY-ESO-1 specific TCR (1G4c113), CD3ε&CD3γ, CD3ε&CD3δ, and CD3ζ dimers
Activity
 Immobilized Human NY-ESO-1 TCR&CD3 Complex VLP at 5 ug/mL (100ul/well) on the plate. Dose response curve for OKT3, mFc Tag with the EC50 of 18.2ng/ml determined by ELISA.
Fluorophore
 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by HPLC
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Human NY-ESO-1 TCR&CD3 Complex VLP at 5 ug/mL (100ul/well) on the plate. Dose response curve for OKT3, mFc Tag with the EC50 of 18.2ng/ml determined by ELISA. Immobilized Human NY-ESO-1 TCR&CD3 Complex VLP at 5 ug/mL (100ul/well) on the plate. Dose response curve for OKT3, mFc Tag with the EC50 of 18.2ng/ml determined by ELISA.
Immobilized Human NY-ESO-1 TCR&CD3 Complex VLP at 5 ug/mL (100ul/well) on the plate. Dose response curve for Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer, His Tag (Cat. MHC-HM405) with the EC50 of 7.5ng/ml determined by ELISA. Immobilized Human NY-ESO-1 TCR&CD3 Complex VLP at 5 ug/mL (100ul/well) on the plate. Dose response curve for Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer, His Tag (Cat. MHC-HM405) with the EC50 of 7.5ng/ml determined by ELISA.
The purity of Human NY-ESO-1 TCR&CD3 Complex VLP is greater than 95% as determined by SEC-HPLC. The purity of Human NY-ESO-1 TCR&CD3 Complex VLP is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
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