Name: Human Oncostatin M/OSM Protein (ONM-HM101)
Brand: KactusBio
SKU: ONM-HM101-100UG
Price: 247.5 USD
Availability: InStock

Human Oncostatin M/OSM Protein (ONM-HM101)

Human LIF R, hFc Tag captured on CM5 Chip via Protein A can bind Human OSM, His Tag with an affinity constant of 0.884 uM as determined in SPR assay (Biacore T200).

Human Oncostatin M on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.The ED50-for this effect is 0.3-1 ng/mL (QC Test).

The purity of Human Oncostatin M is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 0.884 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Ala26-Arg221

Catalog #ONM-HM101

Size

100UG

500UG

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Product Description	Recombinant Human Oncostatin M/OSM Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ala26-Arg221.
Product Background	OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Product Category	Recombinant Protein / Antibody discovery

Protein	Oncostatin M/OSM
Synonyms	Oncostatin M; OSM; MGC20461
Accession	P13725
Species	Human
Biotinylated	no
Amino Acid Range	Ala26-Arg221
Molecular Weight	The protein has a predicted MW of 23.24 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 0.884 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human LIF R, hFc Tag captured on CM5 Chip via Protein A can bind Human OSM, His Tag with an affinity constant of 0.884 uM as determined in SPR assay (Biacore T200).
	Human Oncostatin M on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.The ED50-for this effect is 0.3-1 ng/mL (QC Test).
	The purity of Human Oncostatin M is greater than 95% as determined by SEC-HPLC.