Human OSMR Protein (OSM-HM201)

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Human OSMR, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-OSMR Antibody, hFc Tag with the EC50 of 9.4ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Glu28-Met740

Catalog: OSM-HM201

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Product Description	Recombinant Human OSMR Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Glu28-Met740.
Product Background	OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.
Product Category	Recombinant Protein

Target	OSMR
Accession	Q99650-1
Species	Human
Amino Acid Range	Glu28-Met740
Molecular Weight	The protein has a predicted MW of 107.06 kDa. Due to glycosylation, the protein migrates to 120-140 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human OSMR, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-OSMR Antibody, hFc Tag with the EC50 of 9.4ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-hFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human OSMR, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-OSMR Antibody, hFc Tag with the EC50 of 9.4ng/ml determined by ELISA.
	The purity of Human OSMR is greater than 95% as determined by SEC-HPLC.
	Human OSMR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.