Name: Human PBK/TOPK Protein (PBK-HB101)
Brand: KactusBio
SKU: PBK-HB101-100UG
Price: 315.0 USD
Availability: InStock

Catalog #PBK-HB101

Size

100UG

500UG

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Product Description	Recombinant Human PBK/TOPK Protein is expressed from Baculovirus-Insect Cells(Sf9) with His tag at the C-terminus.It contains Met1-Val322.
Product Background	T-lymphokine-activated killer cell-originated protein kinase (TOPK, also known as PDZ-binding kinase or PBK) plays a crucial role in cell cycle regulation and mitotic progression. Abnormal overexpression or activation of TOPK has been observed in many cancers, including colorectal cancer, triple-negative breast cancer, and melanoma, and it is associated with increased development, dissemination, and poor clinical outcomes and prognosis in cancer. Moreover, TOPK phosphorylates p38, JNK, ERK, and AKT, which are involved in many cellular functions, and participates in the activation of multiple signaling pathways related to MAPK, PI3K/PTEN/AKT, and NOTCH1.
Product Category	Recombinant Protein / Antibody discovery

Protein	PBK/TOPK
Synonyms	CT84; Nori-3; Nori3; SPK; TOPK; PBK
Accession	Q96KB5-1
Species	Human
Biotinylated	no
Amino Acid Range	Met1-Val322
Molecular Weight	The protein has a predicted MW of 37.61 kDa. Due to glycosylation, the protein migrates to 38-45 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	Baculovirus-Insect Cells(Sf9)
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.