Name: Human PD-1/PDCD1 Protein (PD1-HM601)
Brand: KactusBio
SKU: PD1-HM601-100UG
Price: 330.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-Llama IgG2b Fc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human PD-1, Llama Fc Tag at 1ug/ml(100ul/well) on the plate. Dose response curve for Human PD-L1, mFc Tag with the EC50 of 45.2ng/ml determined by ELISA.
Amino Acid Range: Leu25-Gln167

Catalog #PD1-HM601

Size

100UG

500UG

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Human PD-1/PDCD1 Protein (PD1-HM601) Summary

Product Description	Recombinant Human PD-1/PDCD1 Protein is expressed from HEK293 with Llama IgG2b Fc tag at the C-terminus.It contains Leu25-Gln167.
Product Background	Programmed Death-1 receptor (PD-1), also known as CD279, is type I transmembrane protein belonging to the CD28 family of immune regulatory receptors.PD1 is a inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Human PD-1/PDCD1 Protein (PD1-HM601) Specifications/Details

Protein	PD-1/PDCD1
Synonyms	PDCD1; PD1; CD279; SLEB2; PD-1
Accession	Q15116-1
Species	Human
Biotinylated	no
Amino Acid Range	Leu25-Gln167
Molecular Weight	The protein has a predicted MW of 43.26 kDa. Due to glycosylation, the protein migrates to 65-80 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human PD-1, Llama Fc Tag at 1ug/ml(100ul/well) on the plate. Dose response curve for Human PD-L1, mFc Tag with the EC50 of 45.2ng/ml determined by ELISA.
Product Tag	C-Llama IgG2b Fc
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human PD-1, Llama Fc Tag at 1ug/ml(100ul/well) on the plate. Dose response curve for Human PD-L1, mFc Tag with the EC50 of 45.2ng/ml determined by ELISA.
	Human PD-1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Biotinylated Human PD-L2, His Tag on Anti-His-Biosensor can bind Human PD-1, Llama IgG2b Fc Tag with an affinity constant of 16.3 nM as determined in BLI assay .
	The purity of Human PD-1 is greater than 95% as determined by SEC-HPLC.

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