Name: Human PD-L2/B7-DC Protein (PDL-HM202)
Brand: KactusBio
SKU: PDL-HM202-100UG
Price: 240.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Bis-Tris PAGE
Activity: The affinity constant of 0.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Leu20-Thr220

Catalog #PDL-HM202

Size

100UG

500UG

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Product Description	Recombinant Human PD-L2/B7-DC Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Leu20-Thr220.
Product Background	PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.
Product Category	Recombinant Protein

Protein	PD-L2/B7-DC
Synonyms	PDL2; PD-L2; Butyrophilin B7-DC; CD273, PDCD1 ligand 2; PDCD1L2; PDCD1LG2; B7DC; bA574F11.2; Btdc
Accession	Q9BQ51
Species	Human
Biotinylated	no
Amino Acid Range	Leu20-Thr220
Molecular Weight	The protein has a predicted MW of 48.60 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 0.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Human PD-L2, hFc Tag captured on CM5 Chip via Protein A can bind Human PD-1, His Tag with an affinity constant of 0.21 uM as determined in SPR assay (Biacore T200).
	Human PD-L2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human PD-L2 is greater than 95% as determined by SEC-HPLC.

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