Human PD-L2/B7-DC Protein (PDL-HM202)

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Tris-Bis PAGE
Activity: The affinity constant of 0.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Leu20-Thr220

Catalog: PDL-HM202

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Product Description	Recombinant Human PD-L2/B7-DC Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Leu20-Thr220.
Product Background	PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.
Product Category	Recombinant Protein

Target	PD-L2/B7-DC
Accession	Q9BQ51
Species	Human
Amino Acid Range	Leu20-Thr220
Molecular Weight	The protein has a predicted MW of 48.60 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 0.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-hFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human PD-L2, hFc Tag captured on CM5 Chip via Protein A can bind Human PD-1, His Tag with an affinity constant of 0.21 uM as determined in SPR assay (Biacore T200).
	The purity of Human PD-L2 is greater than 95% as determined by SEC-HPLC.
	Human PD-L2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.