Human PD-L2/B7-DC Protein (PDL-HM202)
Human PD-L2/B7-DC Protein (PDL-HM202)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: The affinity constant of 0.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Leu20-Thr220
Catalog #PDL-HM202
Regular price $240.00
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Product Description
Recombinant Human PD-L2/B7-DC Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Leu20-Thr220.
Product Background
PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.
Product Category
Recombinant Protein
Target
PD-L2/B7-DC
Synonyms
PDL2; PD-L2; Butyrophilin B7-DC; CD273, PDCD1 ligand 2; PDCD1L2; PDCD1LG2; B7DC; bA574F11.2; Btdc
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Leu20-Thr220
Molecular Weight
The protein has a predicted MW of 48.60 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity
The affinity constant of 0.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
C-hFc
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human PD-L2, hFc Tag captured on CM5 Chip via Protein A can bind Human PD-1, His Tag with an affinity constant of 0.21 uM as determined in SPR assay (Biacore T200).
Human PD-L2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human PD-L2 is greater than 95% as determined by SEC-HPLC.

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