Name: Human PGLYRP1 Protein (PGL-HM201)
Brand: KactusBio
SKU: PGL-HM201-100UG
Price: 330.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-hFc (IgG1)
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 17.39 µM as determined in SPR assay (Biacore T200).
Amino Acid Range: Gln22-Pro196
Other Available Proteins:

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Catalog #PGL-HM201

Size

100UG

500UG

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Human PGLYRP1 Protein (PGL-HM201) Summary

Product Description	Recombinant Human PGLYRP1 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Gln22-Pro196.
Product Background	Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery/Others

Human PGLYRP1 Protein (PGL-HM201) Specifications/Details

Protein	PGLYRP1
Synonyms	PGRP-S; PGLYRP1; PGLYRP; PGRP; TNFSF3L; PGRP-SMGC126894; PGRPSMGC126896; TAG7; Tasg7
Accession	O75594
Species	Human
Biotinylated	no
Amino Acid Range	Gln22-Pro196
Molecular Weight	The protein has a predicted MW of 46.2 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 17.39 µM as determined in SPR assay (Biacore T200).
Product Tag	C-hFc (IgG1)
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human PGLYRP1, hFc Tag captured on CM5 Chip via Protein A can bind Human TREM1, His Tag (Cat. TRM-HM101) with an affinity constant of 17.39 µM as determined in SPR assay (Biacore T200).
	Human PGLYRP1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Human TREM1, His Tag (Cat. TRM-HM101) on Anti-His-Biosensor can bind Human PGLYRP1, hFc Tag with an affinity constant of 32.90 nM as determined in BLI assay (Gator® Prime).
	The purity of Human PGLYRP1 is greater than 95% as determined by SEC-HPLC.