Name: Human PLAU/uPA Protein (active form) (PLA-HM101)
Brand: KactusBio
SKU: PLA-HM101-100UG
Price: 330.0 USD
Availability: InStock

Human PLAU/uPA Protein (active form) (PLA-HM101)

Human PLAU (activated by trypsin) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human PLAU (activated by trypsin) is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Amino Acid Range: Ser21-Leu431

Catalog #PLA-HM101

Size

100UG

500UG

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Product Description	Recombinant Human PLAU/uPA Protein (active form) is expressed from HEK293 with His tag at the C-Terminus.It contains Ser21-Leu431, which consists of two chains: Long chain A (Ser21-Phe177) and chain B (Ile179-Leu431). The long chain A is further cleaved to yield a short chain A (Lys156-Phe177) and N-Terminus fragment (Ser21-Lys155).
Product Background	Plasminogen activator, urokinase (uPA) is a secreted serine protease, cleaving the sequence Cys-Pro-Gly-Arg560-Val561-Val-Gly-Gly-Cys in plasminogen to form plasmin. Dysregulation of PLAU is often accompanied by various cancers and PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC.
Product Category	Recombinant Protein / Antibody discovery

Protein	PLAU/uPA
Synonyms	PLAU; Urokinase; ATF; UPA; URK; u-PA; BDPLT5; QPD
Accession	P00749-1
Species	Human
Biotinylated	no
Amino Acid Range	Ser21-Leu431
Molecular Weight	The protein has a predicted MW of 17.9 kDa (long chain A), 29.2 kDa (chain B) and 15.3 kDa (N-terminal fragment). The protein migrates to 30-38 kDa and 17 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in 1% HCOOH, 1 mM DTT (pH 3.0). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in 1% HCOOH, 1mM DTT (pH 3.0).
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human PLAU (activated by trypsin) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human PLAU (activated by trypsin) is greater than 95% as determined by SEC-HPLC.