Human PLVAP Protein (PVP-HM101)
Human PLVAP Protein (PVP-HM101)
  • Express System: HEK293
  • Product Tag: N-His
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Amino Acid Range: Tyr49-Gly442
Catalog #PVP-HM101
Regular price $315.00
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Product Description
Recombinant Human PLVAP Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Tyr49-Gly442.
Product Background
Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such as high glucose and vascular endothelial growth factor (VEGF) induce its expression, leading to the exacerbation of cellular permeability. Because the new blood vessels are fragile and leaky, PLVAP could possibly be considered a therapeutic target against retinovascular diseases.
Product Category
Recombinant Protein
Target
PLVAP
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Tyr49-Gly442
Molecular Weight
The protein has a predicted MW of 45.97 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Product Tag
N-His
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS, 200mM L-arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human PLVAP on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

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