• Express System: HEK293
  • Product Tag: C-hFc (IgG1)
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human PRLR, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-PRLR Antibody, hFc Avi Tag with the EC50 of 7.9ng/ml determined by ELISA.
  • Amino Acid Range: Gln25-Asp234
Catalog #PLR-HM201
Price
Regular price $330.00
Regular price Sale price $330.00
/
Size
Avantor VWR Fisher Scientific

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Human PRLR Protein (PLR-HM201) Summary

Product Description

 Recombinant Human PRLR Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Gln25-Asp234.

Product Background

 Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers.

Product Category

 Recombinant Protein / Antibody discovery / ADC targets

Human PRLR Protein (PLR-HM201) Specifications/Details

Protein
 PRLR
Synonyms
 PRL-R; HPRL; MFAB; Prolactin R
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Gln25-Asp234
Molecular Weight
 The protein has a predicted MW of 50.36 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human PRLR, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-PRLR Antibody, hFc Avi Tag with the EC50 of 7.9ng/ml determined by ELISA.
Product Tag
 C-hFc (IgG1)

Fluorophore

 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS, 8% trehalose (pH 7.4).
Reconstitution
 Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
 -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Human PRLR, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-PRLR Antibody, hFc Avi Tag with the EC50 of 7.9ng/ml determined by ELISA. Immobilized Human PRLR, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-PRLR Antibody, hFc Avi Tag with the EC50 of 7.9ng/ml determined by ELISA.
Human PRLR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human PRLR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human PRLR is greater than 95% as determined by SEC-HPLC. The purity of Human PRLR is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...
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support@kactusbio.us

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