Human PRLR Protein, Ultra Low Endotoxin (PLR-HM101-UL)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human PRLR, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-PRLR Antibody, hFc Tag with the EC50 of 28.2ng/ml determined by ELISA (QC Test). The affinity constant of 0.96nM as determined in SPR assay (Biacore T200).
Amino Acid Range: Gln25-Asp234

Catalog #PLR-HM101-UL

Price

$327.00

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Human PRLR Protein, Ultra Low Endotoxin (PLR-HM101-UL) Summary

Product Description	Recombinant Human PRLR Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln25-Asp234.
Product Background	Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers.
Product Category	Recombinant Protein / Antibody discovery / ADC targets

Protein	PRLR
Synonyms	PRL-R; HPRL; MFAB; Prolactin R
Accession	P16471-1
Species	Human
Biotinylated	no
Amino Acid Range	Gln25-Asp234
Molecular Weight	The protein has a predicted MW of 25.5 kDa. Due to glycosylation, the protein migrates to 35-40 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human PRLR, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-PRLR Antibody, hFc Tag with the EC50 of 28.2ng/ml determined by ELISA (QC Test). The affinity constant of 0.96nM as determined in SPR assay (Biacore T200).
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.01 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in 50mM Tris, 150nM Nacl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human PRLR, His Tag captured on CM5 Chip via anti-His antibody can bind Anti-PRLR Antibody, hFc Tag with an affinity constant of 0.96nM as determined in SPR assay (Biacore T200).
	Immobilized Human PRLR, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-PRLR Antibody, hFc Tag with the EC50 of 28.2ng/ml determined by ELISA (QC Test).
	Human PRLR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human PRLR is greater than 95% as determined by SEC-HPLC.

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