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Human Prostatic Acid Phosphatase Protein (ACP-HM101) Summary
Product Description |
Recombinant Human Prostatic Acid Phosphatase Protein is expressed from HEK293 with His tag at the C-terminus.It contains Lys33-Asp386. |
Product Background |
Human PAcP is classically known as a prostate epithelium-specific 100 kDa glycoprotein [20], consisting of two subunits with molecular weight of about 50 kDa each [21]. In normal differentiated prostate epithelia, PAcP protein can be detected intracellularly as the cellular form (cPAcP) and in seminal fluid as the secretory form (sPAcP). The two forms of PAcP protein are apparently transcribed from the same gene followed by different post-transcriptional modifications. Circulating PAcP activity is serving as a surrogate marker for diagnosing PCa as well as for evaluating the efficacy of ADT for advanced PCa. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Human Prostatic Acid Phosphatase Protein (ACP-HM101) Specifications/Details
Protein |
Prostatic Acid Phosphatase |
Synonyms |
PAP; 5'-NT; ACPP; ACP-3; TMPase; TM-PAP |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Lys33-Asp386 |
Molecular Weight |
The protein has a predicted MW of 42.61 kDa. Due to glycosylation, the protein migrates to 48-60 kDa based on Bis-Tris PAGE result. |
Activity |
Measured by its ability to cleave a substrate, p-Nitrophenyl phosphate (pNPP). The specific activity is >90000 pmol/min/ug. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in 20mM NaAc, 20% Glycerol (pH 5.0). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human Prostatic Acid Phosphatase on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human Prostatic Acid Phosphatase is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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