Human Proteinase-activated receptor 1/PAR-1 VLP (PAR-HM01R) Summary
Product Description |
Recombinant Human Proteinase-activated receptor 1/PAR-1 VLP is expressed from HEK293.It contains Met1-Thr425 (It may have cross reaction with anti-His antibody). |
Product Background |
Proteinase activated receptors (PAR 1-4) are membrane receptors with a unique way of activation by proteinases like thrombin, trypsin and matrix metalloproteinases which lead to a specific cellular response. PAR-1 was present in adenocarcinomas, melanomas, osteosarcomas, glioblastomas, meningiomas, leukaemias and squamous cell carcinomas. PAR-1 is widely expressed in human tumors suggesting an important role in tumorigenesis and providing potential targets for therapy. |
Product Category |
Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / VLP |
Human Proteinase-activated receptor 1/PAR-1 VLP (PAR-HM01R) Specifications/Details
Protein |
Proteinase-activated receptor 1/PAR-1 |
Synonyms |
Proteinase-activated receptor 1; PAR-1; Coagulation factor II receptor; Thrombin receptor; F2R; CF2R; PAR1; TR |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Thr425 |
Molecular Weight |
The protein has a predicted MW of 48.79 kDa. |
Activity |
Immobilized Human PAR-1 VLP at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-PAR-1 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test). See testing image for detail. |
Expression System |
HEK293 |
Purity |
> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 150mM L-Arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized Human PAR-1 VLP at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-PAR-1 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test). |
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The purity of Human PAR-1 VLP is greater than 95% as determined by SEC-HPLC. |
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