Product Description |
Recombinant Human PS20 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Lys32-Gln220. |
Product Background |
The whey acidic protein family member, WFDC1/ps20 is a permissivity factor in HIV infection. Herein we describe a contrasting role for ps20 in limiting MHV-1 infection. Intranasal MHV-1 infection produces a respiratory infection in mice. Using ps20 knockout mice we provide evidence that intranasal MHV-1 infection results in increased lung viral titers in ps20(-/-) compared to ps20(/) mice. Roles for ps20 in regulating expression of neutrophil-specific chemotactic factors, thereby potentially modulating neutrophil migration, and in modulating neutrophil susceptibility to MHV-1 infection. |
Product Category |
Recombinant Protein |
Target |
PS20 |
Synonyms |
Ps20; Wfdc1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Lys32-Gln220 |
Molecular Weight |
The protein has a predicted MW of 22 kDa. The protein migrates to 25-30 kDa based on Bis-Tris PAGE result. |
Product Tag |
N-His |
Express System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in 20mM PB, 500mM NaCl, 200mM L-arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human PS20 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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