Name: Human PVRIG Protein, Ultra Low Endotoxin (PVR-HM302-UL)
Brand: KactusBio
SKU: PVR-HM302-UL-100UG
Price: 399.0 USD
Availability: InStock

Human PVRIG Protein, Ultra Low Endotoxin (PVR-HM302-UL)

Human PVRIG, mFc Tag captured on CM5 Chip via Protein A can bind Human Nectin-2, His Tag with an affinity constant of 87.49 nM as determined in SPR assay (Biacore T200).

Immobilized Human Nectin-2, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human PVRIG, mFc Tag with the EC50 of 92.1ng/ml determined by ELISA (QC Test).

Immobilized Human PVRIG, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-PVRIG Antibody, hFc Tag with the EC50 of 9.4ng/ml determined by ELISA.

Human PVRIG on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human PVRIG is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-mFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human Nectin-2, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human PVRIG, mFc Tag with the EC50 of 92.1ng/ml determined by ELISA (QC Test). The affinity constant of 87.49 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Thr41-Asp171

Catalog #PVR-HM302-UL

Size

100UG

500UG

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Product Description	Recombinant Human PVRIG Protein is expressed from HEK293 with mFc (IgG2a) tag at the C-terminus.It contains Thr41-Asp171.
Product Background	Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.PVRIG is a cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Protein	PVRIG
Synonyms	C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1
Accession	Q6DKI7
Species	Human
Biotinylated	no
Amino Acid Range	Thr41-Asp171
Molecular Weight	The protein has a predicted MW of 40.03 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human Nectin-2, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human PVRIG, mFc Tag with the EC50 of 92.1ng/ml determined by ELISA (QC Test). The affinity constant of 87.49 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-mFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.01 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human PVRIG, mFc Tag captured on CM5 Chip via Protein A can bind Human Nectin-2, His Tag with an affinity constant of 87.49 nM as determined in SPR assay (Biacore T200).
	Immobilized Human Nectin-2, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human PVRIG, mFc Tag with the EC50 of 92.1ng/ml determined by ELISA (QC Test).
	Immobilized Human PVRIG, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-PVRIG Antibody, hFc Tag with the EC50 of 9.4ng/ml determined by ELISA.
	Human PVRIG on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human PVRIG is greater than 95% as determined by SEC-HPLC.