Human RAGE/AGER Protein (AER-HM201)

Express System: HEK293
Product Tag: C-hFc (IgG1)
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Amino Acid Range: Ala23-Ala342

Catalog #AER-HM201

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Human RAGE/AGER Protein (AER-HM201) Summary

Product Description

Recombinant Human RAGE/AGER Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Ala23-Ala342.

Product Background

The receptor for advanced glycation end products (AGER) is an oncogenic transmembranous receptor up-regulated in various human cancers. AGER promotes proliferation, migration, and inhibits apoptosis of squamous cervical cancer and might function as a tumor promoter in cervical cancer. Our study provides novel evidence for a potential role of AGER in bridging human papillomavirus (HPV)-induced inflammation and cervical cancer.

Human RAGE/AGER Protein (AER-HM201) Specifications/Details

Protein	RAGE
Synonyms	AGER; RAGE; SCARJ1
Accession	Q15109-1
Species	Human
Biotinylated	no
Amino Acid Range	Ala23-Ala342
Molecular Weight	The protein has a predicted MW of 59.92 kDa. Due to glycosylation, the protein migrates to 80-90 kDa based on Bis-Tris PAGE result.
Product Tag	C-hFc (IgG1)
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Human RAGE on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human RAGE is greater than 95% as determined by SEC-HPLC.