Name: Human SEMA4B Protein (SEM-HM14B)
Brand: KactusBio
SKU: SEM-HM14B-100UG
Price: 280.5 USD
Availability: InStock

Catalog #SEM-HM14B

Size

100UG

500UG

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Product Description	Recombinant Human SEMA4B Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu44-Glu717.
Product Background	Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.
Product Category	Recombinant Protein / Antibody discovery

Protein	SEMA4B
Synonyms	Semaphorin-4B; Semaphorin-C; SEMA4B; KIAA1745; SEMAC; MGC131831; SemC
Accession	Q9NPR2
Species	Human
Biotinylated	no
Amino Acid Range	Leu44-Glu717
Molecular Weight	The protein has a predicted MW of 75.8 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human SEMA4B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human SEMA4B is greater than 95% as determined by SEC-HPLC.