Name: Human SEMA7A Protein (SEM-HM17A)
Brand: KactusBio
SKU: SEM-HM17A-100UG
Price: 270.0 USD
Availability: InStock

Catalog #SEM-HM17A

Size

100UG

500UG

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Product Description	Recombinant Human SEMA7A Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln45-Ala648.
Product Background	Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain.Sema7A is upregulated in the epileptic brain and plays a potential role in the regulation of seizure activity in PTZ-kindled epileptic rats, which may be related to neuroinflammation. Sema7A promotes the inflammatory cytokines TNF-α and IL-6 as well as the growth of mossy fibers through the ERK pathway, suggesting that Sema7A may promote seizures by increasing neuroinflammation and activating pathological neural circuits. Sema7A plays a critical role in epilepsy and could be a potential therapeutic target for this neurological disorder.
Product Category	Recombinant Protein / Antibody discovery

Protein	SEMA7A
Synonyms	Semaphorin-7A; Semaphorin-K1; Semaphorin-L; Sema L; CD108; CD108MGC126696; CDw108; H-SEMA-K1; H-Sema-L; JMH; MGC126692; Sema7A; SEMAK1; SEMAL
Accession	O75326-1
Species	Human
Biotinylated	no
Amino Acid Range	Gln45-Ala648
Molecular Weight	The protein has a predicted MW of 69.5 kDa. Due to glycosylation, the protein migrates to 70-75 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human SEMA7A on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human SEMA7A is greater than 95% as determined by SEC-HPLC.