Human SEMA7A Protein (SEM-HM27A)

Express System: HEK293
Product Tag: C-hFc (IgG1)
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Amino Acid Range: Gln45-Ala648

Catalog #SEM-HM27A

Price

$315⁰⁰

Size

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Human SEMA7A Protein (SEM-HM27A) Summary

Product Description

Recombinant Human SEMA7A Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Gln45-Ala648.

Product Background

Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain.Sema7A is upregulated in the epileptic brain and plays a potential role in the regulation of seizure activity in PTZ-kindled epileptic rats, which may be related to neuroinflammation. Sema7A promotes the inflammatory cytokines TNF-α and IL-6 as well as the growth of mossy fibers through the ERK pathway, suggesting that Sema7A may promote seizures by increasing neuroinflammation and activating pathological neural circuits. Sema7A plays a critical role in epilepsy and could be a potential therapeutic target for this neurological disorder.

Human SEMA7A Protein (SEM-HM27A) Specifications/Details

Protein	SEMA7A
Synonyms	Semaphorin-7A; Semaphorin-K1; Semaphorin-L; Sema L; CD108; CD108MGC126696; CDw108; H-SEMA-K1; H-Sema-L; JMH; MGC126692; Sema7A; SEMAK1; SEMAL
Accession	O75326-1
Species	Human
Biotinylated	no
Amino Acid Range	Gln45-Ala648
Molecular Weight	The protein has a predicted MW of 94.38 kDa. Due to glycosylation, the protein migrates to 105-125 kDa based on Bis-Tris PAGE result.
Product Tag	C-hFc (IgG1)
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Human SEMA7A on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human SEMA7A is greater than 95% as determined by SEC-HPLC.