Name: Human SEZ6 Protein (SEZ-HM106)
Brand: KactusBio
SKU: SEZ-HM106-100UG
Price: 390.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: Immobilized Human SEZ6, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 9.0 ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Leu20-His925

Catalog #SEZ-HM106

Size

100UG

500UG

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Product Description	Recombinant Human SEZ6 Protein is expressed from HEK293 with His tag at the C-Terminus; It contains Leu20-His925.
Product Background	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	SEZ6
Synonyms	SEZ-6; SEZ6; BSRPC; BSRP-C
Accession	Q53EL9-1
Species	Human
Biotinylated	no
Amino Acid Range	Leu20-His925
Molecular Weight	The protein has a predicted MW of 98.9 kDa. Due to glycosylation, the protein migrates to 145-150 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human SEZ6, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 9.0 ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human SEZ6, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 9.0 ng/ml determined by ELISA (QC Test).
	Human SEZ6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Anti-SEZ6 Antibody, hFc Tag on ProA-Biosensor can bind Human SEZ6, His Tag with an affinity constant of 17.70 nM as determined in BLI assay (Gator® Prime).
	The purity of Human SEZ6 is greater than 90% as determined by SEC-HPLC.