Product Description |
Recombinant Human SEZ6 Protein is expressed from HEK293 with His tag at the C-Terminus; It contains Leu20-His925. |
Product Background |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. |
Product Category |
Recombinant Protein |
Target |
SEZ6 |
Synonyms |
SEZ-6; SEZ6; BSRPC; BSRP-C |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Leu20-His925 |
Molecular Weight |
The protein has a predicted MW of 98.9 kDa. Due to glycosylation, the protein migrates to 145-150 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human SEZ6, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 9.0 ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Human SEZ6, His Tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 9.0 ng/ml determined by ELISA. |
|
|
Human SEZ6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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