Human SEZ6 Protein (SEZ-HM106)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Activity: Immobilized Human SEZ6, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 13.2ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Leu20-His925

Catalog: SEZ-HM106

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Product Description Recombinant Human SEZ6 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu20-His925.

Product Background

Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.

Product Category

Recombinant Protein

Target

SEZ6
Synonyms SEZ-6; SEZ6; BSRPC; BSRP-C

Gene/Protein ID

Q53EL9-1

Species

Human

Exact Sequence

Leu20-His925
Molecular Weight The protein has a predicted MW of 98.9 kDa. Due to glycosylation, the protein migrates to 145-150 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human SEZ6, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 13.2ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human SEZ6, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 13.2ng/ml determined by ELISA.
Human SEZ6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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