Product Description |
Recombinant Human SEZ6 Sushi4 Domain Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Gln769-Leu832. |
Product Background |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Protein |
SEZ6 |
Synonyms |
SEZ-6; SEZ6; BSRPC; BSRP-C |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln769-Leu832 |
Molecular Weight |
The protein has a predicted MW of 32.94 kDa. Due to glycosylation, the protein migrates to 40-48 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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