Human Siglec-5/CD170 Protein (SIG-HM205)
Human Siglec-5/CD170 Protein (SIG-HM205)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Glu17-Thr434
Catalog #SIG-HM205
Regular price $231.00
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Product Description

Recombinant Human Siglec-5/CD170 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu17-Thr434.

Product Background

Interactions between endothelial selectins and the leukocyte counter-receptor PSGL1 mediates leukocyte recruitment to inflammation sites. PSGL1 is highly sialylated, making it a potential ligand for Siglec-5, a leukocyte-receptor that recognizes sialic acid structures. Binding assays using soluble Siglec-5 variants (sSiglec-5/C4BP and sSiglec-5/Fc) revealed a dose- and calcium-dependent binding to PSGL1.

Product Category

Recombinant Protein / Antibody discovery

Protein

Siglec-5/CD170

Synonyms

CD170; CD33 antigen-like 2; CD33L2; OBBP2; Siglec5; SIGLEC5; OB-BP2

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Glu17-Thr434

Molecular Weight

The protein has a predicted MW of 73.1 kDa. Due to glycosylation, the protein migrates to 90-115 kDa based on Bis-Tris PAGE result.

Product Tag

C-hFc

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human Siglec-5 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. Human Siglec-5 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
The purity of Human Siglec-5 is greater than 95% as determined by SEC-HPLC. The purity of Human Siglec-5 is greater than 95% as determined by SEC-HPLC.

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