Human Siglec-5/CD170 Protein (SIG-HM205)
Human Siglec-5/CD170 Protein (SIG-HM205)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Glu17-Thr434
Catalog #SIG-HM205
Regular price $210.00
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Product Description
Recombinant Human Siglec-5/CD170 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu17-Thr434.
Product Background
Interactions between endothelial selectins and the leukocyte counter-receptor PSGL1 mediates leukocyte recruitment to inflammation sites. PSGL1 is highly sialylated, making it a potential ligand for Siglec-5, a leukocyte-receptor that recognizes sialic acid structures. Binding assays using soluble Siglec-5 variants (sSiglec-5/C4BP and sSiglec-5/Fc) revealed a dose- and calcium-dependent binding to PSGL1.
Product Category
Recombinant Protein
Target
Siglec-5/CD170
Synonyms
CD170; CD33 antigen-like 2; CD33L2; OBBP2; Siglec5; SIGLEC5; OB-BP2
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Glu17-Thr434
Molecular Weight
The protein has a predicted MW of 73.1 kDa. Due to glycosylation, the protein migrates to 90-115 kDa based on Bis-Tris PAGE result.
Product Tag
C-hFc
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human Siglec-5 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
The purity of Human Siglec-5 is greater than 95% as determined by SEC-HPLC.

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