Human Siglec-8 Protein (SIG-HM208)
Catalog: SIG-HM208
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| Product Description | Recombinant Human Siglec-8 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Met17-Ala363. |
Product Background |
Siglec-8, also known as SAF, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains.Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. |
Product Category |
Recombinant Protein |
Target |
Siglec-8 |
| Synonyms | CDw329; MGC59785; SAF2; SAF2SAF-2; Siglec-8; SIGLEC8L; SIGLEC8 |
Gene/Protein ID |
Q9NYZ4 |
Species |
Human |
Exact Sequence |
Met17-Ala363 |
| Molecular Weight | The protein has a predicted MW of 64.6 kDa. Due to glycosylation, the protein migrates to 70-82 kDa based on Tris-Bis PAGE result. |
Product Tag |
C-hFc |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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The purity of-Human Siglec-8 is greater than 95% as determined by SEC-HPLC. |
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Human Siglec-8 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%. |
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