Human Siglec-8 Protein (SIG-HM208)
Human Siglec-8 Protein (SIG-HM208)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Met17-Ala363
Catalog #SIG-HM208
Regular price $315.00
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Size

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Product Description

Recombinant Human Siglec-8 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Met17-Ala363.

Product Background

Siglec-8, also known as SAF, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains.Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid.

Product Category

Recombinant Protein / Antibody discovery

Protein

Siglec-8

Synonyms

CDw329; MGC59785; SAF2; SAF2SAF-2; Siglec-8; SIGLEC8L; SIGLEC8

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Met17-Ala363

Molecular Weight

The protein has a predicted MW of 64.6 kDa. Due to glycosylation, the protein migrates to 70-82 kDa based on Bis-Tris PAGE result.

Product Tag

C-hFc

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human Siglec-8 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. Human Siglec-8 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
The purity of-Human Siglec-8 is greater than 95% as determined by SEC-HPLC. The purity of-Human Siglec-8 is greater than 95% as determined by SEC-HPLC.

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support@kactusbio.us

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