Human SMPD1 Protein (SMD-HB101)

  • Express System: Baculovirus-Insect Cells
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Met1-Pro628

Catalog: SMD-HB101


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Product Description Recombinant Human SMPD1 Protein is expressed from Baculovirus-Insect Cells with His tag at the C-terminus.It contains Met1-Pro628.

Product Background

Sphingomyelin phosphodiesterase 1 (SMPD1) converts sphingomyelin into ceramide and phosphocholine; hence, loss of SMPD1 function causes abnormal accumulation of sphingomyelin in lysosomes, which results in the lipid-storage disorder Niemann-Pick disease (types A and B). SMPD1 activity is dependent on zinc, which is coordinated at the active site of the enzyme.

Product Category

Recombinant Protein



Gene/Protein ID




Exact Sequence

Molecular Weight The protein has a predicted MW of 66.53 kDa. Due to glycosylation, the protein migrates to 67-70 kDa based on Tris-Bis PAGE result.

Product Tag


Express System

Baculovirus-Insect Cells
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in 20mM Tris, 500mM NaCl, 25% glycerol (pH 7.5).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Measured by its ability to cleave 2-N-Hexadecanoylamino-4-nitrophenylphosphorylcholine (HNPPC). The specific activity is > 1500 pmol/min/ug, as measured under the described conditions.
The purity of Human SMPD1 is greater than 95% as determined by SEC-HPLC.
Human SMPD1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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