• Express System: E.coli
  • Product Tag: No Tag
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human Tau-441(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 1.0ng/ml determined by ELISA.
  • Amino Acid Range: Met1-Leu441(P301L)
Catalog #TAU-HE042
Price
Regular price $330.00
Regular price Sale price $330.00
/
Size
Avantor VWR Fisher Scientific

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Human Tau-441/2N4R(P301L) Protein (TAU-HE042) Summary

Product Description

 Recombinant Human Tau-441/2N4R (P301L) Protein is expressed from E.coli without tag.It contains Met1-Leu441(P301L).

Product Background

 Mutations in MAPT, the tau gene, give rise to frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), with abundant flamentous tau inclusions in brain cells. Mutations that encode missense variants of residue P301 are the most common and result in the formation of flamentous inclusions made of mutant four-repeat tau. In vitro experiments have shown that, of the MAPT mutations tested, P301L and P301S tau had the least potential to promote microtubule assembly and the greatest ability to form heparin-induced filaments.

Product Category

 Recombinant Protein / Antibody discovery / Antibody discovery/Others

Human Tau-441/2N4R(P301L) Protein (TAU-HE042) Specifications/Details

Protein
 Tau-441/2N4R
Synonyms
 PHF-tau; MAPT; MTBT1; TAU; Tau-F; Tau-4; 2N4R; DDPAC; FTDP-17; MSTD
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Met1-Leu441(P301L)
Molecular Weight
 The protein has a predicted MW of 45.86 kDa. The protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human Tau-441(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 1.0ng/ml determined by ELISA.
Product Tag
 No Tag

Fluorophore

 Unconjugated
Expression System
 E.coli
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Human Tau-441(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 1.0ng/ml determined by ELISA. Immobilized Human Tau-441(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 1.0ng/ml determined by ELISA.
Human Tau-441(P301L) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human Tau-441(P301L) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human Tau-441(P301L) is greater than 95% as determined by SEC-HPLC. The purity of Human Tau-441(P301L) is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...
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