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Human Tau-441/2N4R Protein (TAU-HE041) Summary
Product Description |
Recombinant Human Tau-441/2N4R Protein is expressed from E.coli without tag.It contains Met1-Leu441. |
Product Background |
As a major microtubule-associated protein, tau plays an important role in promoting microtubule assembly and stabilizing microtubules. In Alzheimer's disease (AD) and other tauopathies, the abnormally hyperphosphorylated tau proteins are aggregated into paired helical filaments and accumulated in the neurons with the form of neurofibrillary tangles. An imbalanced regulation in protein kinases and protein phosphatases is the direct cause of tau hyperphosphorylation. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Human Tau-441/2N4R Protein (TAU-HE041) Specifications/Details
Protein |
Tau-441/2N4R |
Synonyms |
PHF-tau; MAPT; MTBT1; TAU; Tau-F; Tau-4; 2N4R; DDPAC; FTDP-17; MSTD |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Leu441 |
Molecular Weight |
The protein has a predicted MW of 45.84 kDa. The protein migrates to 60-70 kDa based on Bis-Tris PAGE result. |
Product Tag |
No Tag |
Fluorophore |
Unconjugated |
Expression System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in 25mM HEPES, 0.25M NaCl, 10% Glycerol, 1mM TCEP (pH 7.2). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human Tau-441 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human Tau-441 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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