• Express System: E.coli
  • Product Tag: No Tag
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human Tau K18(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 0.6ng/ml determined by ELISA.
  • Amino Acid Range: Gln244-Glu372(P301L)
Catalog #TAU-HE043
Price
Regular price $420.00
Regular price Sale price $420.00
/
Size
Avantor VWR Fisher Scientific

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Human Tau K18(P301L) Protein (TAU-HE043) Summary

Product Description

 Recombinant Human Tau K18(P301L) Protein is expressed from E.coli without tag.It contains Gln244-Glu372(P301L).

Product Background

 K18, a 126-residue peptide containing the four repeats of the tubulin-binding domain of tau is driven by phosphorylation to form liquid–liquid phase-separated (LLPS) droplets, a state from which full-length tau further condenses to form amyloid fibrils. K18, which like tau is strongly cationic, also can be seeded to form amyloid-like filaments by preformed tau amyloid and by complementary anionic polymers and compounds and accordingly has been used as a model for analyses of factors controlling amyloid assembly.

Product Category

 Recombinant Protein / Antibody discovery / Antibody discovery/Others

Human Tau K18(P301L) Protein (TAU-HE043) Specifications/Details

Protein
 Tau K18
Synonyms
 PHF-tau; MAPT; MTBT1; TAU; Tau-F; Tau-4; 2N4R; DDPAC; FTDP-17; MSTD
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Gln244-Glu372(P301L)
Molecular Weight
 The protein has a predicted MW of 13.69 kDa same as Bis-Tris PAGE result.
Activity
 Immobilized Human Tau K18(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 0.6ng/ml determined by ELISA.
Product Tag
 No Tag

Fluorophore

 Unconjugated
Expression System
 E.coli
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Human Tau K18(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 0.6ng/ml determined by ELISA. Immobilized Human Tau K18(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 0.6ng/ml determined by ELISA.
Human Tau K18(P301L) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human Tau K18(P301L) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human Tau K18(P301L) is greater than 95% as determined by SEC-HPLC. The purity of Human Tau K18(P301L) is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...
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