Human Tau K18(P301L) Protein (TAU-HE043)

Immobilized Human Tau K18(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 0.6ng/ml determined by ELISA.

Human Tau K18(P301L) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human Tau K18(P301L) is greater than 95% as determined by SEC-HPLC.

Express System: E.coli
Product Tag: No Tag
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human Tau K18(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 0.6ng/ml determined by ELISA.
Amino Acid Range: Gln244-Glu372(P301L)

Catalog #TAU-HE043

Price

$420⁰⁰

Size

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Human Tau K18(P301L) Protein (TAU-HE043) Summary

Product Description

Recombinant Human Tau K18(P301L) Protein is expressed from E.coli without tag.It contains Gln244-Glu372(P301L).

Product Background

K18, a 126-residue peptide containing the four repeats of the tubulin-binding domain of tau is driven by phosphorylation to form liquid–liquid phase-separated (LLPS) droplets, a state from which full-length tau further condenses to form amyloid fibrils. K18, which like tau is strongly cationic, also can be seeded to form amyloid-like filaments by preformed tau amyloid and by complementary anionic polymers and compounds and accordingly has been used as a model for analyses of factors controlling amyloid assembly.

Human Tau K18(P301L) Protein (TAU-HE043) Specifications/Details

Protein	Tau K18
Synonyms	PHF-tau; MAPT; MTBT1; TAU; Tau-F; Tau-4; 2N4R; DDPAC; FTDP-17; MSTD;Tau4; FTDP17
Accession	P10636-8
Species	Human
Biotinylated	no
Amino Acid Range	Gln244-Glu372(P301L)
Molecular Weight	The protein has a predicted MW of 13.69 kDa same as Bis-Tris PAGE result.
Activity	Immobilized Human Tau K18(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 0.6ng/ml determined by ELISA.
Product Tag	No Tag
Fluorophore	Unconjugated
Expression System	E.coli
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Human Tau K18(P301L), No Tag at 0.5ug/ml(100ul/well) on the plate. Dose response curve for Etalanetug, hFc Tag with the EC50 of 0.6ng/ml determined by ELISA.
	Human Tau K18(P301L) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human Tau K18(P301L) is greater than 95% as determined by SEC-HPLC.