Human TGF-beta RII/TGFBR2 Protein (TGF-HM5R2)
Human TGF-beta RII/TGFBR2 Protein (TGF-HM5R2)
  • Express System: HEK293
  • Product Tag: N-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human Mature TGF beta 1, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human TGF-beta RII, hFc Tag with the EC50 of 11.0ng/ml determined by ELISA (QC Test). The affinity constant of 2.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Ile24-Asp159
Catalog #TGF-HM5R2
Regular price $300.00
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Product Description
Recombinant Human TGF-beta RII/TGFBR2 Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Ile24-Asp159.
Product Background
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division.
Product Category
Recombinant Protein
Target
TGF-beta RII/TGFBR2
Synonyms
TGFR2; TGFBR2; TbetaR-II; TGFβR2; TbetaR-II; TGFβR2; AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Ile24-Asp159
Molecular Weight
The protein has a predicted MW of 44.2 kDa. Due to glycosylation, the protein migrates to 50-68 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Human Mature TGF beta 1, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human TGF-beta RII, hFc Tag with the EC50 of 11.0ng/ml determined by ELISA (QC Test). The affinity constant of 2.21 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
N-hFc
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human TGF-beta RII, hFc Tag captured on CM5 Chip via Protein A can bind Human Latent TGF beta 2, His Tag with an affinity constant of 2.21 uM as determined in SPR assay (Biacore T200).
Immobilized Human Mature TGF beta 1, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human TGF-beta RII, hFc Tag with the EC50 of 11.0ng/ml determined by ELISA (QC Test).
Human TGF-beta RII on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human TGF-beta RII is greater than 95% as determined by SEC-HPLC.

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