• Express System: HEK293
  • Product Tag: C-Llama Fc
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: Immobilized Human TIM-3, LIama Fc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-TIM-3 Antibody, hFc Tag with the EC50 of 0.14ug/ml determined by ELISA.
  • Amino Acid Range: Ser22-Arg200
Catalog #TIM-HM631
Price
Regular price $375.00
Regular price Sale price $375.00
/
Size
Avantor VWR Fisher Scientific

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Human TIM-3/HAVCR2 Protein (TIM-HM631) Summary

Product Description

 Recombinant Human TIM-3/HAVCR2 Protein is expressed from HEK293 with Llama Fc tag at the C--terminus.It contains Ser22-Arg200.

Product Background

 Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene.TIM3 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8 T-cell exhaustion. TIM3 has also been shown as a CD4 Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.

Product Category

 Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Human TIM-3/HAVCR2 Protein (TIM-HM631) Specifications/Details

Protein
 TIM-3/HAVCR2
Synonyms
 CD366; TIM3; TIM-3; TIMD-3; TIM 3;-FLJ14428; HAVCR2; KIM3
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Ser22-Arg200
Molecular Weight
 The protein has a predicted MW of 47.18 kDa. Due to glycosylation, the protein migrates to 70-90 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human TIM-3, LIama Fc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-TIM-3 Antibody, hFc Tag with the EC50 of 0.14ug/ml determined by ELISA.
Product Tag
 C-Llama Fc

Fluorophore

 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE
Endotoxin
 Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
 -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Human TIM-3, LIama Fc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-TIM-3 Antibody, hFc Tag with the EC50 of 0.14ug/ml determined by ELISA. Immobilized Human TIM-3, LIama Fc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-TIM-3 Antibody, hFc Tag with the EC50 of 0.14ug/ml determined by ELISA.
Human TIM-3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human TIM-3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Other Available Proteins:
Finding available proteins...
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