Name: Human TIM-3/HAVCR2 Protein (TIM-HM631)
Brand: KactusBio
SKU: TIM-HM631-100UG
Price: 375.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-Llama Fc
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Human TIM-3, LIama Fc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-TIM-3 Antibody, hFc Tag with the EC50 of 0.14ug/ml determined by ELISA.
Amino Acid Range: Ser22-Arg200

Catalog #TIM-HM631

Size

100UG

500UG

Order by 4pm ET for delivery on:

Human TIM-3/HAVCR2 Protein (TIM-HM631) Summary

Product Description	Recombinant Human TIM-3/HAVCR2 Protein is expressed from HEK293 with Llama Fc tag at the C--terminus.It contains Ser22-Arg200.
Product Background	Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene.TIM3 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8 T-cell exhaustion. TIM3 has also been shown as a CD4 Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Human TIM-3/HAVCR2 Protein (TIM-HM631) Specifications/Details

Protein	TIM-3/HAVCR2
Synonyms	CD366; TIM3; TIM-3; TIMD-3; TIM 3;-FLJ14428; HAVCR2; KIM3
Accession	Q8TDQ0-1
Species	Human
Biotinylated	no
Amino Acid Range	Ser22-Arg200
Molecular Weight	The protein has a predicted MW of 47.18 kDa. Due to glycosylation, the protein migrates to 70-90 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human TIM-3, LIama Fc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-TIM-3 Antibody, hFc Tag with the EC50 of 0.14ug/ml determined by ELISA.
Product Tag	C-Llama Fc
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human TIM-3, LIama Fc Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-TIM-3 Antibody, hFc Tag with the EC50 of 0.14ug/ml determined by ELISA.
	Human TIM-3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Other Available Proteins:

Finding available proteins...

Loading...