Name: Human TNFRSF11A/Rank Protein (RNK-HM211)
Brand: KactusBio
SKU: RNK-HM211-100UG
Price: 346.5 USD
Availability: InStock

Express System: HEK293
Product Tag: C-hFc (IgG1)
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human RANKL, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TNFRSF11A, hFc Tag with the EC50 of 8.8ng/ml determined by ELISA.
Amino Acid Range: Ile30-Pro212
Other Available Proteins:

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Catalog #RNK-HM211

Size

100UG

500UG

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Human TNFRSF11A/Rank Protein (RNK-HM211) Summary

Product Description	Recombinant Human TNFRSF11A/Rank Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Ile30-Pro212.
Product Background	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery/Others

Human TNFRSF11A/Rank Protein (RNK-HM211) Specifications/Details

Protein	TNFRSF11A/Rank
Synonyms	ODFR; Receptor activator of NF-KB; NF-KB; NFKB; CD265; TNFRSF11A; Rank; FEO; LOH18CR1; OPTB7; OSTS; PDB2; TRANCER;
Accession	Q9Y6Q6-1
Species	Human
Biotinylated	no
Amino Acid Range	Ile30-Pro212
Molecular Weight	The protein has a predicted MW of 46.85 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human RANKL, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TNFRSF11A, hFc Tag with the EC50 of 8.8ng/ml determined by ELISA.
Product Tag	C-hFc (IgG1)
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human RANKL, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human TNFRSF11A, hFc Tag with the EC50 of 8.8ng/ml determined by ELISA.
	Human TNFRSF11A on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human TNFRSF11A is greater than 95% as determined by SEC-HPLC.

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