Human tPA Protein (TPA-HM10A)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Measured by its ability to cleave a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The specific activity is > 200 pmol/min/ug.
Amino Acid Range: Ser36-Pro562

Catalog #TPA-HM10A

Price

$297.00

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Human tPA Protein (TPA-HM10A) Summary

Product Description	Recombinant Human tPA Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ser36-Pro562, which consists of two chains: chain A (Ser36-Arg310) and chain B (Ile311-Pro562).
Product Background	Tissue plasminogen activator (tPA) is the predominant plasminogen activator present in the vascular and nervous systems.t tPA is not only neuroprotective for postnatal primary cortical neurons, but also that the predominant route for enhancing cell survival is via an mTORdependent mechanism.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery/Others

Protein	tPA
Synonyms	t-PA; tPA; Alteplase; Reteplase; PLAT;
Accession	P00750-1
Species	Human
Biotinylated	no
Amino Acid Range	Ser36-Pro562
Molecular Weight	The protein has a predicted MW of 60.13 kDa. It migrates to 40-45 kDa and 35-40 kDa based on Bis-Tris PAGE result.
Activity	Measured by its ability to cleave a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The specific activity is > 200 pmol/min/ug.
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22um filtered solution in 20mM MES, 300mM NaCl, 200mM Arginine (pH 5.5).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Human tPA on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

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