Product Description |
Recombinant Human TPM1-Protein is expressed from E.coli with His tag at the N-Terminus.It contains Met1-Met284. |
Product Background |
Tropomyosin-1 (TPM1), a widely expressed actin-binding protein, is downregulated in many tumors and associated with cancer progression. TPM1 overexpression in RCC cell lines can induce tumor cell apoptosis via the p53-mediated mitochondrial pathway. Further studies are needed to fully elucidate the potential of TPM1 as a candidate for RCC targeted therapy in the future. |
Product Category |
Recombinant Protein |
Target |
TPM1 |
Synonyms |
C15orf13; TMSA; CMD1Y; CMH3; HTM-alpha; LVNC9 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Met284 |
Molecular Weight |
The protein has a predicted MW of 34.26 kDa same as Bis-Tris PAGE result. |
Product Tag |
N-His |
Express System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS, 150mM NaCl (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human TPM1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human TPM1 is greater than 90% as determined by SEC-HPLC. |
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