Product Description |
Recombinant Human Thyroid Peroxidase Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe19-Arg846. |
Product Background |
Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase that encodes a 933 amino-acid residue (aa) molecule with a single membrane-spanning region. Thyroid peroxidase plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues and the coupling of iodotyrosine residues in Tg, resulting in the formation of T3 and T4. It is a frequent epitope of autoantibodies in autoimmune thyroid disease, for example, the expression of thyroid peroxidase is lost in papillary thyroid carcinoma. |
Product Category |
Recombinant Protein |
Target |
Thyroid Peroxidase |
Synonyms |
TPO; THPO; MGC163194; MGDF; MKCSF; ML; MPLLG; THCYT1; MGDFC-mpl ligand; MK-CSF; MPL ligand; Thyroperoxidase; TPOMKCSF |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Phe19-Arg846 |
Molecular Weight |
The protein has a predicted MW of 90.6 kDa. Due to glycosylation, the protein migrates to 95-105 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in 20mM Tris, 500mM NaCl, 10% Glycerol (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human Thyroid Peroxidase on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human Thyroid Peroxidase is greater than 95% as determined by SEC-HPLC. |
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