Name: Human Thyroid Peroxidase Protein (TPO-HM101)
Brand: KactusBio
SKU: TPO-HM101-100UG
Price: 375.0 USD
Availability: InStock

HPLC chromatogram of purified protein showing a single dominant peak at retention time 8.102 minutes, indicating high purity.

Human Thyroid Peroxidase Protein (TPO-HM101)

Human Thyroid Peroxidase on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human Thyroid Peroxidase is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Amino Acid Range: Phe19-Arg846

Catalog #TPO-HM101

Size

100UG

500UG

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Human Thyroid Peroxidase Protein (TPO-HM101) Summary

Product Description	Recombinant Human Thyroid Peroxidase Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe19-Arg846.
Product Background	Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase that encodes a 933 amino-acid residue (aa) molecule with a single membrane-spanning region. Thyroid peroxidase plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues and the coupling of iodotyrosine residues in Tg, resulting in the formation of T3 and T4. It is a frequent epitope of autoantibodies in autoimmune thyroid disease, for example, the expression of thyroid peroxidase is lost in papillary thyroid carcinoma.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Human Thyroid Peroxidase Protein (TPO-HM101) Specifications/Details

Protein	Thyroid Peroxidase
Synonyms	Thyroid peroxidase; TPO
Accession	P07202-1
Species	Human
Biotinylated	no
Amino Acid Range	Phe19-Arg846
Molecular Weight	The protein has a predicted MW of 90.6 kDa. Due to glycosylation, the protein migrates to 95-105 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human Thyroid Peroxidase on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human Thyroid Peroxidase is greater than 95% as determined by SEC-HPLC.