Human TYRO3 Protein (TYR-HM103)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 2.36 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Exact Sequence: Ala41-Trp429

Catalog: TYR-HM103

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Product Description	Recombinant Human TYRO3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala41-Trp429.
Product Background	The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the "eat-me" signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.
Product Category	Recombinant Protein

Target	TYRO3
Synonyms	BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse
Gene/Protein ID	Q06418
Species	Human
Exact Sequence	Ala41-Trp429
Molecular Weight	The protein has a predicted MW of 42.8 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 2.36 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Human GAS6, His Tag immobilized on CM5 Chip can bind Human TYRO3, His Tag with an affinity constant of 2.36 uM as determined in SPR assay (Biacore T200).
	The purity of Human TYRO3 is greater than 95% as determined by SEC-HPLC.
	Human TYRO3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.