Human ULBP-4 Protein (ULB-HM204)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 0.17 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: His31-Asp225
Catalog #ULB-HM204
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Product Description
 Recombinant Human ULBP-4 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains His31-Asp225.
Product Background
 UL16-binding proteins (ULBPs) are markers of cellular stress which are upregulated on the surface of virus-infected and tumor cells. ULBPs are expressed by a variety of leukemias, carcinomas, melanomas, and tumor cell lines.ULBP4 is associated with higher levels of CD8+/NKG2D+ lymphocytes infiltrating the carcinoma and is a prognosticator of improved survival.
Product Category
 Recombinant Protein
Target
 ULBP-4
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 His31-Asp225
Molecular Weight
 The protein has a predicted MW of 49.12 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity
 The affinity constant of 0.17 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
 C-hFc
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human ULBP-4, hFc Tag captured on CM5 Chip via Protein A can bind Human NKG2D, His Tag with an affinity constant of 0.17 uM as determined in SPR assay (Biacore T200).
Human ULBP-4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human ULBP-4 is greater than 95% as determined by SEC-HPLC.
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