Product Description |
Recombinant Human VCAM-1/CD106 Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Phe25-Glu698. |
Product Background |
Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine that triggers the expression of inflammatory molecules, including other cytokines and cell adhesion molecules. TNFα induces the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 (VCAM-1). VCAM-1 was originally identified as a cell adhesion molecule that helps regulate inflammation-associated vascular adhesion and the transendothelial migration of leukocytes, such as macrophages and T cells. |
Product Category |
Recombinant Protein |
Target |
VCAM-1/CD106 |
Synonyms |
V-CAM 1; VCAM-1; INCAM-100; CD106; DKFZp779G2333; MGC99561 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Phe25-Glu698 |
Molecular Weight |
The protein has a predicted MW of 100.17 kDa. Due to glycosylation, the protein migrates to 105-125 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human VCAM-1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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