Product Description |
Recombinant Human VEGF R2/KDR Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Ala20-Glu764. |
Product Background |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. |
Product Category |
Recombinant Protein |
Target |
VEGF R2/KDR |
Synonyms |
CD309; KDR; VEGFR; VEGFR2; VEGFR-21; FLK1; KRD1; Ly73 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ala20-Glu764 |
Molecular Weight |
The protein has a predicted MW of 110 kDa. Due to glycosylation, the protein migrates to 150-200 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human VEGF165 1ug/ml (100ul/Well) on the plate. Dose response curve for Human VEGF R2, mFc Tag with the EC50 of 42.3ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-mFc |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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|
Immobilized Human VEGF165 1ug/ml (100ul/Well) on the plate. Dose response curve for Human VEGF R2, mFc Tag with the EC50 of 42.3ng/ml determined by ELISA. |
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Human VEGF R2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human VEGF R2 is greater than 95% as determined by SEC-HPLC. |
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