Product Description |
Recombinant Human YKL-40/CHI3L1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Tyr22-Thr383. |
Product Background |
YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in several neurological and neurodegenerative diseases associated with inflammatory processes. Yet the precise characterization of YKL-40 in dementia cases is missing. YKL-40 is a disease-specific marker of neuroinflammation showing its highest levels in prion diseases. Therefore, YKL-40 quantification might have a potential for application in the evaluation of therapeutic intervention in dementias with a neuroinflammatory component. |
Product Category |
Recombinant Protein |
Target |
YKL-40/CHI3L1 |
Synonyms |
BRP39; CGP-39; GP-39; Chil1; ASRT7; FLJ38139; HC-gp39; YKL-40; YKL40; YYL-40; AW208766; CHI3L1; Chitinase 3 like 1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Tyr22-Thr383 |
Molecular Weight |
The protein has a predicted MW of 41.6 kDa. Due to glycosylation, the protein migrates to 42-50 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human YKL-40, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-YKL-40 Antibody, hFc Tag with the EC50 of 38.2ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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|
Immobilized Human YKL-40, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-YKL-40 Antibody, hFc Tag with the EC50 of 38.2ng/ml determined by ELISA (QC Test). |
|
|
Human YKL-40 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human YKL-40 is greater than 95% as determined by SEC-HPLC. |
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