Name: Human YKL-40/CHI3L1 Protein (YKL-HM140)
Brand: KactusBio
SKU: YKL-HM140-100UG
Price: 231.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human YKL-40, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-YKL-40 Antibody, hFc Tag with the EC50 of 38.2ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Tyr22-Thr383

Catalog #YKL-HM140

Size

100UG

500UG

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Product Description	Recombinant Human YKL-40/CHI3L1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Tyr22-Thr383.
Product Background	YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in several neurological and neurodegenerative diseases associated with inflammatory processes. Yet the precise characterization of YKL-40 in dementia cases is missing. YKL-40 is a disease-specific marker of neuroinflammation showing its highest levels in prion diseases. Therefore, YKL-40 quantification might have a potential for application in the evaluation of therapeutic intervention in dementias with a neuroinflammatory component.
Product Category	Recombinant Protein / Antibody discovery

Protein	YKL-40/CHI3L1
Synonyms	BRP39; CGP-39; GP-39; Chil1; ASRT7; FLJ38139; HC-gp39; YKL-40; YKL40; YYL-40; AW208766; CHI3L1; Chitinase 3 like 1
Accession	P36222
Species	Human
Biotinylated	no
Amino Acid Range	Tyr22-Thr383
Molecular Weight	The protein has a predicted MW of 41.6 kDa. Due to glycosylation, the protein migrates to 42-50 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human YKL-40, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-YKL-40 Antibody, hFc Tag with the EC50 of 38.2ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human YKL-40, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-YKL-40 Antibody, hFc Tag with the EC50 of 38.2ng/ml determined by ELISA (QC Test).
	Human YKL-40 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human YKL-40 is greater than 95% as determined by SEC-HPLC.