Human YKL-40/CHI3L1 Protein (YKL-HM140)
Human YKL-40/CHI3L1 Protein (YKL-HM140)
Human YKL-40/CHI3L1 Protein (YKL-HM140)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human YKL-40, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-YKL-40 Antibody, hFc Tag with the EC50 of 38.2ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Tyr22-Thr383
Catalog #YKL-HM140
Regular price $210.00
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Product Description
Recombinant Human YKL-40/CHI3L1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Tyr22-Thr383.
Product Background
YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in several neurological and neurodegenerative diseases associated with inflammatory processes. Yet the precise characterization of YKL-40 in dementia cases is missing. YKL-40 is a disease-specific marker of neuroinflammation showing its highest levels in prion diseases. Therefore, YKL-40 quantification might have a potential for application in the evaluation of therapeutic intervention in dementias with a neuroinflammatory component.
Product Category
Recombinant Protein
Target
YKL-40/CHI3L1
Synonyms
BRP39; CGP-39; GP-39; Chil1; ASRT7; FLJ38139; HC-gp39; YKL-40; YKL40; YYL-40; AW208766; CHI3L1; Chitinase 3 like 1
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Tyr22-Thr383
Molecular Weight
The protein has a predicted MW of 41.6 kDa. Due to glycosylation, the protein migrates to 42-50 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Human YKL-40, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-YKL-40 Antibody, hFc Tag with the EC50 of 38.2ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
C-His
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human YKL-40, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-YKL-40 Antibody, hFc Tag with the EC50 of 38.2ng/ml determined by ELISA (QC Test).
Human YKL-40 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human YKL-40 is greater than 95% as determined by SEC-HPLC.

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